PIK3IP1

Across TCGA cell cohorts, PIK3IP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,745 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PIK3IP1-associated GO terms across cancer lineages are DNA replication checkpoint signaling, rRNA 5'-end processing, and Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with PIK3IP1 in more than 14 cancer types. Because this analysis shows association rather than direction, both PIK3IP1-to-partner and partner-to-PIK3IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by PIK3IP1-low versus PIK3IP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3IP1→partner) and Y-score (partner→PIK3IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication checkpoint signaling →	-0.179	-1.589	.004	.001	3	15
BONE	rRNA 5'-end processing →	-0.127	-1.543	<.001	.003	3	14
BONE	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.127	-1.543	<.001	.003	3	14
LIVER	Cellular response to nutrient levels →	+0.057	+1.799	<.001	.008	3	13
BONE	DNA replication initiation →	-0.177	-1.568	.001	.002	3	13
OVARY	Regulation of protein localization to cell periphery →	+0.098	+1.315	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,745 associations by consensus.

DNA replication checkpoint signaling by PIK3IP1 expression — BONE

Explore this box plot interactively →