Across TCGA pan-cancer cohorts, PIK3IP1-DT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PIK3IP1-DT’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PIK3IP1-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIK3IP1-DT is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
BLCA, KIRC, and COAD are the cancer types where PIK3IP1-DT tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3IP1-DT RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.