PIK3CG

Across TCGA pan-cancer cohorts, PIK3CG Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PIK3CG data layer compared with 28 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PIK3CG Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3CG expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LUAD, UCEC, and HNSC are the cancer types where PIK3CG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.105	0.675	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.951	0.296	.001	36	view →
HNSC	DFS	Median	III,IV	1.000	0.576	.014	24	view →
PAAD	OS	Median	All	0.112	0.640	.004	12	view →
GBM	DFS	Median	All	0.072	0.244	.013	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →
KIRC	OS	Median	All	0.622	0.874	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PIK3CG–LUAD (OS)

Open the LUAD breakdown →