PIK3CG

Across TCGA patient cohorts, PIK3CG mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3CG-associated genes across cancer lineages are Caspase-7-cleavedD198, mTOR_pS2448, and c-Kit. Each is linked with PIK3CG in more than 4 cancer types. Because this analysis shows association rather than direction, both PIK3CG-to-partner and partner-to-PIK3CG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PIK3CG-low versus PIK3CG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CG→partner) and Y-score (partner→PIK3CG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.709	+2.523	<.001	<.001	3	5
COAD	mTOR_pS2448 →	-0.136	-1.861	.027	.049	3	4
STAD	c-Kit →	-0.413	-3.169	.003	.018	3	3
LUAD	p27_pT198 →	+0.151	+1.765	.001	.013	3	3
LUAD	Raptor →	+0.186	+1.891	.014	.027	3	3
COAD	ERK2 →	+0.161	+3.459	.016	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Caspase-7-cleavedD198 by PIK3CG expression — UCEC

Explore this box plot interactively →