PIK3CG

Across TCGA cell cohorts, PIK3CG RNA expression is significantly associated with the go_rna of many other GO terms, with 2,761 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3CG-associated GO terms across cancer lineages are Positive regulation of gene expression, epigenetic, Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration, and Regulation of hemostasis. Each is linked with PIK3CG in more than 5 cancer types. Because this analysis shows association rather than direction, both PIK3CG-to-partner and partner-to-PIK3CG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of gene expression, epigenetic grouped by PIK3CG-low versus PIK3CG-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CG→partner) and Y-score (partner→PIK3CG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of gene expression, epigenetic →	+0.043	+1.077	.001	<.001	3	6
BLOOD_Leukemia	Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration →	+0.080	+0.654	<.001	.007	3	6
CNS	Regulation of hemostasis →	+0.129	+0.265	.002	.002	3	5
BLOOD_Leukemia	Regulation of vasculature development →	+0.044	+1.423	<.001	<.001	3	5
CNS	Regulation of blood coagulation →	+0.130	+0.253	<.001	.002	3	5
BLOOD_Leukemia	Regulation of angiogenesis →	+0.041	+1.284	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,761 associations by consensus.

Positive regulation of gene expression, epigenetic by PIK3CG expression — BLOOD_Leukemia

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