PIK3CG

Across TCGA cell cohorts, PIK3CG mutation is significantly associated with the RNA expression of many other genes, with 685 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3CG-associated genes across cancer lineages are DPH5, SLC35A3, and PAIP2B. Each is linked with PIK3CG in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3CG-to-partner and partner-to-PIK3CG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPH5 grouped by PIK3CG-low versus PIK3CG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CG→partner) and Y-score (partner→PIK3CG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DPH5 →	+0.650	+3.502	<.001	.001	3	2
LARGE_INTESTINE	SLC35A3 →	+0.677	+3.064	.001	.009	3	2
LARGE_INTESTINE	PAIP2B →	+0.709	+3.237	.004	.003	3	2
LARGE_INTESTINE	CCNO →	+0.848	+3.169	.007	.009	3	2
BLOOD_Leukemia	EDA →	+0.836	+3.470	.001	.004	3	2
LARGE_INTESTINE	PPP4R2 →	+0.471	+3.502	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 685 associations by consensus.

DPH5 by PIK3CG expression — LARGE_INTESTINE

Explore this box plot interactively →