PIK3CD

Across TCGA pan-cancer cohorts, PIK3CD mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PIK3CD’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PIK3CD mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PIK3CD is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where PIK3CD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3CD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	+0.764	<.001	12	view →
COAD	All	IV	−0.564	<.001	8	view →
HNSC	Male	II,III,IV	+0.258	<.001	8	view →
PDAC	Female	All	+0.457	.002	4	view →
LSCC	Male	All	−0.139	.003	4	view →
LUAD	All	II,III,IV	−0.105	.024	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PIK3CD–CCRCC

Open the CCRCC breakdown →