PIK3CB

Across TCGA pan-cancer cohorts, PIK3CB Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated PIK3CB data layer compared with 22 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PIK3CB Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PIK3CB expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, HNSC, and PAAD are the cancer types where PIK3CB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.423	.001	36	view →
HNSC	OS	Median	All	0.196	0.769	<.001	24	view →
PAAD	DFS	Median	All	0.060	0.484	<.001	12	view →
LUAD	OS	Median	All	0.292	0.675	.008	8	view →
CESC	DFS	Median	All	0.149	0.740	.001	6	view →
READ	OS	Median	II,III,IV	0.187	0.653	.030	6	view →
LUSC	OS	Median	III,IV	0.112	0.664	.031	6	view →
LIHC	OS	Median	All	0.015	0.784	<.001	6	view →
STAD	DFS	Median	All	1.000	0.388	.031	5	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	III,IV	0.063	0.648	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PIK3CB–UCEC (DFS)

Open the UCEC breakdown →