PIK3CB

Across TCGA pan-cancer cohorts, PIK3CB mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PIK3CB data layer compared with 22 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PIK3CB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIK3CB expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, CCRCC, and COAD are the cancer types where PIK3CB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.638	.014	36	view →
CCRCC	DFS	Tertile	IV	0.260	0.887	.024	11	view →
COAD	DFS	Median	IV	0.432	0.944	.038	6	view →
PDAC	OS	Tertile	IV	0.425	0.973	.024	6	view →
HNSC	DFS	Median	All	0.852	0.707	.022	3	view →
GBM	DFS	Quartile	All	0.272	0.500	.042	2	view →
LSCC	DFS	Median	All	0.482	0.888	.016	2	view →
LUAD	OS	Median	II,III,IV	0.784	0.452	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PIK3CB–UCEC (OS)

Open the UCEC breakdown →