PIK3CB

Across TCGA patient cohorts, PIK3CB mutation is significantly associated with the RNA expression of many other genes, with 3,402 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3CB-associated genes across cancer lineages are RNU6ATAC29P, TAF11L14, and AQP7P3. Each is linked with PIK3CB in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3CB-to-partner and partner-to-PIK3CB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6ATAC29P grouped by PIK3CB-low versus PIK3CB-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CB→partner) and Y-score (partner→PIK3CB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6ATAC29P →	+0.381	+3.623	<.001	.004	3	3
LUSC	TAF11L14 →	+0.362	+3.164	<.001	<.001	3	3
LUAD	AQP7P3 →	+0.024	+4.995	<.001	<.001	3	3
SARC	RNU6-1149P →	+1.013	+4.291	<.001	.007	3	2
BRCA	RN7SKP222 →	+0.074	+5.126	.001	.003	3	2
BRCA	LINC02644 →	+0.064	+5.281	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,402 associations by consensus.

RNU6ATAC29P by PIK3CB expression — BLCA

Explore this box plot interactively →