PIK3CB

Across TCGA patient cohorts, PIK3CB mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3CB-associated genes across cancer lineages are MEK1, TIGAR, and Caspase-7-cleavedD198. Each is linked with PIK3CB in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3CB-to-partner and partner-to-PIK3CB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PIK3CB-low versus PIK3CB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CB→partner) and Y-score (partner→PIK3CB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.350	+1.857	.001	<.001	3	2
UCEC	TIGAR →	+0.112	+2.126	.012	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.520	+1.827	.002	.002	3	2
UCEC	4E-BP1 →	+0.277	+2.277	<.001	<.001	3	2
LUSC	FASN →	+0.528	+2.816	.029	.036	3	1
SKCM	AR →	+0.252	+3.000	.004	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MEK1 by PIK3CB expression — UCEC

Explore this box plot interactively →