PIK3CB

Across TCGA cell cohorts, PIK3CB RNA expression is significantly associated with the go_rna of many other GO terms, with 5,089 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3CB-associated GO terms across cancer lineages are Regulation of hypoxia-induced intrinsic apoptotic signaling pathway, Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, and Phosphatidylinositol metabolic process. Each is linked with PIK3CB in more than 10 cancer types. Because this analysis shows association rather than direction, both PIK3CB-to-partner and partner-to-PIK3CB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hypoxia-induced intrinsic apoptotic signaling pathway grouped by PIK3CB-low versus PIK3CB-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CB→partner) and Y-score (partner→PIK3CB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of hypoxia-induced intrinsic apoptotic signaling pathway →	+0.149	+0.605	<.001	.002	3	11
BONE	Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway →	+0.149	+0.605	<.001	.002	3	11
PANCREAS	Phosphatidylinositol metabolic process →	+0.056	+0.853	<.001	<.001	3	11
SOFT_TISSUE	Lysosomal transport →	+0.045	+0.963	<.001	.004	3	11
BLOOD_Lymphoma	Vesicle cytoskeletal trafficking →	+0.048	+0.796	.001	.001	3	10
SOFT_TISSUE	Cytosolic transport →	+0.045	+0.988	.002	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,089 associations by consensus.

Regulation of hypoxia-induced intrinsic apoptotic signaling pathway by PIK3CB expression — BONE

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