PIK3CB

Across TCGA cell cohorts, PIK3CB mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3CB-associated genes across cancer lineages are TREH, NKAIN3, and RTL4. Each is linked with PIK3CB in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3CB-to-partner and partner-to-PIK3CB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TREH grouped by PIK3CB-low versus PIK3CB-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CB→partner) and Y-score (partner→PIK3CB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TREH →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	NKAIN3 →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	RTL4 →	+0.023	+4.807	<.001	.006	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
BLOOD_Lymphoma	ACADL →	+0.098	+3.484	.002	.009	3	1
BLOOD_Lymphoma	OR52K1 →	+0.010	+3.584	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TREH by PIK3CB expression — BLOOD_Myeloma

Explore this box plot interactively →