PIK3CA

Across TCGA pan-cancer cohorts, PIK3CA Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PIK3CA data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PIK3CA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3CA expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCS, CHOL, and SARC are the cancer types where PIK3CA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	II,III,IV	0.353	0.739	<.001	16	view →
CHOL	DFS	Median	All	0.045	0.497	.029	12	view →
SARC	OS	Median	All	0.242	0.751	<.001	12	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
LGG	OS	Median	All	0.749	0.902	<.001	9	view →
SKCM	DFS	Median	All	0.459	0.743	.002	6	view →
UCEC	DFS	Median	All	0.732	0.576	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PIK3CA–UCS (OS)

Open the UCS breakdown →