PIK3CA

Across TCGA pan-cancer cohorts, PIK3CA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIK3CA data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PIK3CA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3CA expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where PIK3CA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.294	0.674	<.001	59	view →
HNSC	OS	Median	All	0.787	0.911	.004	29	view →
LUAD	DFS	Quartile	III,IV	0.465	0.995	.022	9	view →
COAD	DFS	Tertile	III,IV	0.764	1.000	.036	6	view →
CCRCC	OS	Tertile	II,III,IV	0.933	0.757	.017	1	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIK3CA–PDAC (OS)

Open the PDAC breakdown →