PIK3C3

Across TCGA patient cohorts, PIK3C3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,940 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIK3C3-associated proteins across cancer lineages are SMAD4, ZNF24, and RPRD1A. Each is linked with PIK3C3 in more than 8 cancer types. Because this analysis shows association rather than direction, both PIK3C3-to-partner and partner-to-PIK3C3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIK3C3 versus SMAD4 in OV, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C3→partner) and Y-score (partner→PIK3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMAD4 →	+0.311	+0.679	<.001	<.001	3	9
COAD	ZNF24 →	+0.425	+0.485	<.001	<.001	3	6
HNSC	RPRD1A →	+0.453	+0.846	<.001	<.001	3	6
HNSC	SMAD2 →	+0.471	+0.737	<.001	<.001	3	6
LSCC	TXNL1 →	+0.355	+0.593	<.001	<.001	3	6
LUAD	CTDP1 →	+0.215	+0.400	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,940 associations by consensus.

PIK3C3 vs SMAD4 — OV

Explore this scatter interactively →