PIK3C3

Across TCGA patient cohorts, PIK3C3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3C3-associated genes across cancer lineages are MSH2, eEF2, and eIF4E. Each is linked with PIK3C3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3C3-to-partner and partner-to-PIK3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by PIK3C3-low versus PIK3C3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C3→partner) and Y-score (partner→PIK3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.231	-1.899	.001	.004	3	3
UCEC	eEF2 →	+0.244	+1.874	.025	.049	3	2
UCEC	eIF4E →	+0.201	+2.222	.001	<.001	3	2
UCEC	MEK1 →	+0.490	+2.536	<.001	<.001	3	2
UCEC	Notch1 →	+0.195	+2.335	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.715	+1.473	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MSH2 by PIK3C3 expression — UCEC

Explore this box plot interactively →