PIK3C2B

Across TCGA pan-cancer cohorts, PIK3C2B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIK3C2B data layer compared with 24 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PIK3C2B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PIK3C2B expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where PIK3C2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.691	0.318	<.001	33	view →
CCRCC	DFS	Tertile	II,III,IV	0.882	0.486	.005	31	view →
HNSC	DFS	Tertile	All	0.742	0.496	.013	13	view →
UCEC	DFS	Median	All	0.935	1.000	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIK3C2B–PDAC (DFS)

Open the PDAC breakdown →