PIK3C2B

Across TCGA patient cohorts, PIK3C2B mutation is significantly associated with the RNA expression of many other genes, with 5,750 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3C2B-associated genes across cancer lineages are C2CD2, RBFA, and ALAS1. Each is linked with PIK3C2B in more than 3 cancer types. Because this analysis shows association rather than direction, both PIK3C2B-to-partner and partner-to-PIK3C2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2CD2 grouped by PIK3C2B-low versus PIK3C2B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2B→partner) and Y-score (partner→PIK3C2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C2CD2 →	+0.607	+3.470	.005	.002	3	4
UCEC	RBFA →	+0.306	+1.617	<.001	.004	3	4
UCEC	ALAS1 →	+0.343	+1.296	.002	<.001	3	4
UCEC	PSMD5 →	+0.401	+1.938	<.001	<.001	3	4
BRCA	RNU6-1156P →	+0.367	+3.356	.008	.002	3	3
UCEC	COX15 →	+0.355	+2.445	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,750 associations by consensus.

C2CD2 by PIK3C2B expression — BLCA

Explore this box plot interactively →