PIK3C2B

Across TCGA cell cohorts, PIK3C2B mutation is significantly associated with the RNA expression of many other genes, with 1,281 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3C2B-associated genes across cancer lineages are CELA2A, GCAT, and SAMM50. Each is linked with PIK3C2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3C2B-to-partner and partner-to-PIK3C2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA2A grouped by PIK3C2B-low versus PIK3C2B-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2B→partner) and Y-score (partner→PIK3C2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CELA2A →	+0.052	+3.080	.005	.004	3	2
LARGE_INTESTINE	GCAT →	+1.246	+2.130	<.001	<.001	3	2
LARGE_INTESTINE	SAMM50 →	+0.497	+1.721	<.001	.003	3	2
LARGE_INTESTINE	RBM28 →	+0.442	+2.459	.005	.006	3	2
LARGE_INTESTINE	AKAP3 →	+0.751	+3.409	<.001	<.001	3	2
LARGE_INTESTINE	PPP2R5D →	+0.535	+2.064	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,281 associations by consensus.

CELA2A by PIK3C2B expression — BREAST

Explore this box plot interactively →