PIK3C2B

Across TCGA cell cohorts, PIK3C2B mutation is significantly associated with the mutation status of many other genes, with 4,614 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3C2B-associated genes across cancer lineages are CELSR2, GSE1, and KMT2A. Each is linked with PIK3C2B in more than 6 cancer types. Because this analysis shows association rather than direction, both PIK3C2B-to-partner and partner-to-PIK3C2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELSR2 grouped by PIK3C2B-low versus PIK3C2B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2B→partner) and Y-score (partner→PIK3C2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CELSR2 →	+2.874	+2.523	.006	.006	1	7
OVARY	GSE1 →	+2.777	+3.103	.004	.004	1	6
LARGE_INTESTINE	KMT2A →	+2.676	+1.932	<.001	<.001	1	6
STOMACH	PREX1 →	+4.025	+2.942	.009	.009	1	5
SOFT_TISSUE	MCM3AP →	+5.502	+5.502	.003	.003	1	5
STOMACH	LAMA5 →	+2.025	+3.731	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,614 associations by consensus.

CELSR2 by PIK3C2B expression — BLOOD_Lymphoma

Explore this box plot interactively →