PIK3C2A

Across TCGA pan-cancer cohorts, PIK3C2A Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated PIK3C2A data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PIK3C2A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PIK3C2A expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, BLCA, and ESCA are the cancer types where PIK3C2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.925	0.612	.005	34	view →
BLCA	DFS	Median	II,III,IV	0.867	0.314	.002	33	view →
ESCA	OS	Median	II,III,IV	0.124	0.703	<.001	26	view →
LUSC	OS	Median	II,III,IV	0.243	0.633	.013	24	view →
READ	OS	Median	III,IV	0.289	0.932	<.001	15	view →
STAD	DFS	Median	III,IV	1.000	0.331	.026	13	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
KIRP	OS	Median	III,IV	0.268	0.808	.012	6	view →
COAD	OS	Median	All	0.214	0.682	.012	6	view →
SKCM	OS	Median	III,IV	0.282	0.728	.030	6	view →
PRAD	DFS	Median	All	0.176	0.778	<.001	4	view →
LIHC	DFS	Median	All	0.817	0.276	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

PIK3C2A–UCEC (DFS)

Open the UCEC breakdown →