PIK3C2A

Across TCGA pan-cancer cohorts, PIK3C2A mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PIK3C2A data layer compared with 26 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PIK3C2A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIK3C2A expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

GBM and PDAC are the cancer types where PIK3C2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.486	0.299	.025	2	view →
PDAC	DFS	Median	III,IV	0.675	0.349	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PIK3C2A–GBM (OS)

Open the GBM breakdown →