PIK3C2A

Across TCGA patient cohorts, PIK3C2A mutation is significantly associated with the RNA expression of many other genes, with 4,190 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3C2A-associated genes across cancer lineages are RN7SL759P, RNU7-175P, and ATP5IF1. Each is linked with PIK3C2A in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3C2A-to-partner and partner-to-PIK3C2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL759P grouped by PIK3C2A-low versus PIK3C2A-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2A→partner) and Y-score (partner→PIK3C2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RN7SL759P →	+0.074	+7.939	<.001	.008	3	3
KIRP	RNU7-175P →	+1.389	+4.520	<.001	.001	3	3
UCEC	ATP5IF1 →	+0.358	+2.402	<.001	<.001	3	3
LUAD	TRPC7-AS2 →	+0.043	+4.888	<.001	.005	3	2
LUAD	MIR3115 →	+0.722	+5.285	<.001	.001	3	2
KIRP	OR4D11 →	+0.138	+4.645	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,190 associations by consensus.

RN7SL759P by PIK3C2A expression — PRAD

Explore this box plot interactively →