PIK3C2A

Across TCGA patient cohorts, PIK3C2A mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3C2A-associated genes across cancer lineages are EGFR, INPP4B, and TFRC. Each is linked with PIK3C2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3C2A-to-partner and partner-to-PIK3C2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by PIK3C2A-low versus PIK3C2A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2A→partner) and Y-score (partner→PIK3C2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	EGFR →	-0.375	-3.321	.009	.009	3	2
UCEC	INPP4B →	-0.180	-1.584	.042	.015	3	2
SKCM	TFRC →	+0.569	+1.807	.012	.026	3	2
SKCM	CD31 →	-0.161	-2.321	.014	.033	3	2
UCEC	EGFR_pY1068 →	-0.168	-1.152	.014	.048	3	2
UCEC	eIF4E →	+0.129	+1.716	.026	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

EGFR by PIK3C2A expression — BLCA

Explore this box plot interactively →