PIK3C2A

Across TCGA cell cohorts, PIK3C2A mutation is significantly associated with the RNA expression of many other genes, with 449 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3C2A-associated genes across cancer lineages are CEACAM3, SLC12A1, and EIF3D. Each is linked with PIK3C2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3C2A-to-partner and partner-to-PIK3C2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM3 grouped by PIK3C2A-low versus PIK3C2A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2A→partner) and Y-score (partner→PIK3C2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CEACAM3 →	+0.072	+4.927	.009	.001	3	2
OVARY	SLC12A1 →	+0.148	+3.491	<.001	.006	3	2
LARGE_INTESTINE	EIF3D →	+0.423	+2.628	.002	.002	3	2
LARGE_INTESTINE	OR10W1 →	+0.007	+2.655	<.001	.001	3	2
URINARY_TRACT	OR3A2 →	+0.007	+4.584	<.001	.002	3	1
URINARY_TRACT	CROCC2 →	+0.012	+4.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 449 associations by consensus.

CEACAM3 by PIK3C2A expression — BLOOD_Lymphoma

Explore this box plot interactively →