PIK3AP1

Across TCGA pan-cancer cohorts, PIK3AP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIK3AP1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PIK3AP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIK3AP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

COAD, LUAD, and GBM are the cancer types where PIK3AP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.917	1.000	.021	66	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	14	view →
GBM	DFS	Quartile	All	0.234	0.450	.003	8	view →
HNSC	OS	Median	All	1.000	0.484	.038	6	view →
LSCC	DFS	Quartile	All	0.918	0.299	.006	6	view →
PDAC	OS	Median	IV	0.395	0.937	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIK3AP1–COAD (DFS)

Open the COAD breakdown →