PIGZ

Across TCGA pan-cancer cohorts, PIGZ Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIGZ data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PIGZ Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGZ expression acts as an unfavorable survival marker.

COAD, LIHC, and BLCA are the cancer types where PIGZ Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.134	0.794	<.001	24	view →
LIHC	OS	Median	All	0.150	0.786	<.001	15	view →
BLCA	DFS	Median	All	0.078	0.594	<.001	9	view →
LUAD	OS	Median	All	0.241	0.684	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIGZ–COAD (DFS)

Open the COAD breakdown →