PIGZ

Across TCGA patient cohorts, PIGZ mutation is significantly associated with the RNA expression of many other genes, with 974 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGZ-associated genes across cancer lineages are VCY1B, RN7SL400P, and UBTFL5. Each is linked with PIGZ in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGZ-to-partner and partner-to-PIGZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY1B grouped by PIGZ-low versus PIGZ-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGZ→partner) and Y-score (partner→PIGZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VCY1B →	+0.073	+7.731	<.001	.009	3	3
BRCA	RN7SL400P →	+0.514	+9.057	<.001	.003	3	2
CESC	UBTFL5 →	+0.052	+6.569	<.001	.001	3	2
CESC	PDE4DIPP8 →	+0.122	+5.669	<.001	.003	3	2
UCEC	MIR6803 →	+0.161	+4.571	<.001	.002	3	2
COAD	RNU6-819P →	+0.427	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 974 associations by consensus.

VCY1B by PIGZ expression — BRCA

Explore this box plot interactively →