PIGZ

Across TCGA cell cohorts, PIGZ RNA expression is significantly associated with the go_rna of many other GO terms, with 3,945 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PIGZ-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Fatty acid beta-oxidation, and Fatty acid oxidation. Each is linked with PIGZ in more than 13 cancer types. Because this analysis shows association rather than direction, both PIGZ-to-partner and partner-to-PIGZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by PIGZ-low versus PIGZ-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGZ→partner) and Y-score (partner→PIGZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.131	+1.259	.001	.005	3	14
STOMACH	Fatty acid beta-oxidation →	+0.108	+1.393	.001	<.001	3	14
OESOPHAGUS	Fatty acid oxidation →	+0.098	+1.423	<.001	<.001	3	13
URINARY_TRACT	Lipid oxidation →	+0.095	+1.438	.001	<.001	3	13
OESOPHAGUS	Phospholipid biosynthetic process →	+0.054	+1.588	<.001	<.001	3	12
URINARY_TRACT	Fatty acid catabolic process →	+0.097	+1.807	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,945 associations by consensus.

Negative regulation of myoblast fusion by PIGZ expression — OESOPHAGUS

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