PIGZ

Across TCGA cell cohorts, PIGZ mutation is significantly associated with the RNA expression of many other genes, with 173 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGZ-associated genes across cancer lineages are GGTLC2, TMEM82, and OR2AP1. Each is linked with PIGZ in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGZ-to-partner and partner-to-PIGZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGTLC2 grouped by PIGZ-low versus PIGZ-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGZ→partner) and Y-score (partner→PIGZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GGTLC2 →	+0.029	+4.273	.001	.006	3	1
SKIN	TMEM82 →	+0.019	+4.273	.005	.006	3	1
SKIN	OR2AP1 →	+0.012	+5.022	<.001	.002	3	1
SKIN	C2CD4B →	+0.041	+4.684	<.001	.002	3	1
SKIN	CT45A7 →	+0.420	+4.467	<.001	.004	3	1
LARGE_INTESTINE	POLR3H →	+0.949	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 173 associations by consensus.

GGTLC2 by PIGZ expression — SKIN

Explore this box plot interactively →