PIGX

Across TCGA pan-cancer cohorts, PIGX mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIGX data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIGX mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIGX expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where PIGX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.961	0.694	.002	37	view →
PDAC	OS	Median	All	0.768	0.950	.002	12	view →
GBM	DFS	Quartile	All	0.878	0.608	.003	11	view →
LUAD	DFS	Median	II,III,IV	0.773	1.000	.008	8	view →
CCRCC	DFS	Quartile	All	0.845	0.611	.031	4	view →
LSCC	DFS	Median	All	0.972	0.905	.005	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIGX–HNSC (OS)

Open the HNSC breakdown →