PIGX

Across TCGA patient cohorts, PIGX mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGX-associated genes across cancer lineages are LINC00265-3P, CXCR5, and SERPINA9. Each is linked with PIGX in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGX-to-partner and partner-to-PIGX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00265-3P grouped by PIGX-low versus PIGX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGX→partner) and Y-score (partner→PIGX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00265-3P →	+0.037	+4.069	<.001	.008	3	2
UCEC	CXCR5 →	+0.137	+3.609	.005	.003	3	1
UCEC	SERPINA9 →	+0.214	+2.831	.004	.009	3	1
UCEC	TRAJ37 →	+0.973	+2.818	<.001	.005	3	1
UCEC	ATP6V1E1P2 →	+0.357	+4.077	<.001	<.001	3	1
UCEC	SLC25A36P1 →	+0.332	+3.622	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

LINC00265-3P by PIGX expression — UCEC

Explore this box plot interactively →