PIGW

Across TCGA patient cohorts, PIGW mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGW-associated genes across cancer lineages are 14-3-3_beta, JNK_pT183_Y185, and p62 Lck ligand. Each is linked with PIGW in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGW-to-partner and partner-to-PIGW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PIGW-low versus PIGW-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGW→partner) and Y-score (partner→PIGW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.085	-2.973	.035	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.138	-2.459	.041	.019	3	1
UCEC	p62 Lck ligand →	+0.309	+1.884	.018	.030	3	1
UCEC	Rab25 →	-0.292	-2.321	.028	.034	3	1
UCEC	STAT3_pY705 →	-0.303	-1.990	.004	.030	3	1
UCEC	VHL →	-0.585	-2.115	.032	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

14-3-3_beta by PIGW expression — UCEC

Explore this box plot interactively →