PIGV

Across TCGA patient cohorts, PIGV mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGV-associated genes across cancer lineages are ATM, 4E-BP1, and B-Raf. Each is linked with PIGV in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGV-to-partner and partner-to-PIGV results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PIGV-low versus PIGV-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGV→partner) and Y-score (partner→PIGV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.408	-2.000	.046	.032	3	2
UCEC	4E-BP1 →	+0.258	+3.029	.035	.018	3	2
SKCM	B-Raf →	+0.447	+3.000	.032	.035	3	1
UCEC	EGFR_pY1068 →	-0.249	-2.000	.028	.032	3	1
UCEC	INPP4B →	-0.292	-3.169	.045	.018	3	1
UCEC	Ku80 →	+0.321	+3.820	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by PIGV expression — UCEC

Explore this box plot interactively →