PIGT

Across TCGA pan-cancer cohorts, PIGT mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIGT data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PIGT mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGT expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where PIGT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.278	0.754	.001	61	view →
HNSC	DFS	Median	IV	0.527	0.765	.013	18	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	5	view →
UCEC	DFS	Tertile	All	0.758	0.938	.040	4	view →
PDAC	DFS	Quartile	All	0.764	0.882	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIGT–CCRCC (DFS)

Open the CCRCC breakdown →