PIGT

Across TCGA patient cohorts, PIGT mutation is significantly associated with the RNA expression of many other genes, with 1,007 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGT-associated genes across cancer lineages are RNU7-128P, HMOX1, and CENPT. Each is linked with PIGT in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGT-to-partner and partner-to-PIGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-128P grouped by PIGT-low versus PIGT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGT→partner) and Y-score (partner→PIGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU7-128P →	+0.492	+2.216	<.001	.002	3	3
UCEC	HMOX1 →	+1.043	+2.732	<.001	.003	3	2
UCEC	CENPT →	+0.455	+3.756	<.001	<.001	3	2
UCEC	KLHDC4 →	+0.301	+3.491	.009	.002	3	2
UCEC	FCRL5 →	+0.407	+3.552	.002	.002	3	2
BLCA	LAP3P2 →	+0.039	+4.112	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,007 associations by consensus.

RNU7-128P by PIGT expression — UCEC

Explore this box plot interactively →