PIGT

Across TCGA patient cohorts, PIGT mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGT-associated genes across cancer lineages are MSH6, ATM, and eEF2. Each is linked with PIGT in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGT-to-partner and partner-to-PIGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by PIGT-low versus PIGT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGT→partner) and Y-score (partner→PIGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.351	-2.321	.014	.033	3	2
UCEC	ATM →	-0.500	-2.807	.011	.003	3	2
UCEC	eEF2 →	+0.463	+3.321	.003	.009	3	1
UCEC	ERK2 →	+0.233	+2.115	.005	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.312	.038	.034	3	1
UCEC	ACVRL1 →	-0.143	-2.986	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MSH6 by PIGT expression — UCEC

Explore this box plot interactively →