PIGT

Across TCGA cell cohorts, PIGT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,554 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PIGT-associated GO terms across cancer lineages are Attachment of GPI anchor to protein, Membrane protein ectodomain proteolysis, and Carbohydrate derivative catabolic process. Each is linked with PIGT in more than 13 cancer types. Because this analysis shows association rather than direction, both PIGT-to-partner and partner-to-PIGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Attachment of GPI anchor to protein grouped by PIGT-low versus PIGT-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGT→partner) and Y-score (partner→PIGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Attachment of GPI anchor to protein →	+0.158	+0.634	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Membrane protein ectodomain proteolysis →	+0.144	+1.332	.001	.002	3	14
BONE	Carbohydrate derivative catabolic process →	+0.065	+0.696	.007	.006	3	13
SKIN	Multi-pass transmembrane protein insertion into ER membrane →	+0.134	+0.899	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular transport →	+0.069	+0.689	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Membrane protein proteolysis →	+0.144	+0.737	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,554 associations by consensus.

Attachment of GPI anchor to protein by PIGT expression — LIVER

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