PIGT

Across TCGA cell cohorts, PIGT mutation is significantly associated with the RNA expression of many other genes, with 160 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGT-associated genes across cancer lineages are SLC39A12, TOMM22, and RAB3A. Each is linked with PIGT in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGT-to-partner and partner-to-PIGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC39A12 grouped by PIGT-low versus PIGT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGT→partner) and Y-score (partner→PIGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC39A12 →	+0.062	+2.378	<.001	.009	3	2
LARGE_INTESTINE	TOMM22 →	+0.487	+3.169	.002	.009	3	1
LARGE_INTESTINE	RAB3A →	+0.763	+3.234	.004	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+1.339	+3.837	<.001	<.001	3	1
LARGE_INTESTINE	C1QBP →	+0.664	+3.714	.002	<.001	3	1
LARGE_INTESTINE	GAR1 →	+0.507	+3.169	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 160 associations by consensus.

SLC39A12 by PIGT expression — LARGE_INTESTINE

Explore this box plot interactively →