PIGR

Across TCGA pan-cancer cohorts, PIGR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIGR data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PIGR mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIGR expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, GBM, and COAD are the cancer types where PIGR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.631	0.422	<.001	36	view →
GBM	DFS	Quartile	All	0.160	0.437	.017	17	view →
COAD	DFS	Median	III,IV	0.898	1.000	.047	6	view →
UCEC	DFS	Tertile	All	0.942	0.786	.021	4	view →
LUAD	OS	Median	II,III,IV	0.751	0.499	.041	4	view →
CCRCC	OS	Median	IV	0.399	0.932	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIGR–PDAC (OS)

Open the PDAC breakdown →