PIGQ

Across TCGA pan-cancer cohorts, PIGQ mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIGQ data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PIGQ mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIGQ expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where PIGQ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	1.000	0.678	.010	18	view →
LSCC	DFS	Quartile	II,III,IV	0.357	0.791	.010	15	view →
UCEC	OS	Median	III,IV	0.563	1.000	.039	8	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIGQ–CCRCC (OS)

Open the CCRCC breakdown →