Across TCGA patient cohorts, PIGP mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGP-associated genes across cancer lineages are FOXO3a_pS318_S321, NF-kB-p65_pS536, and Notch1. Each is linked with PIGP in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGP-to-partner and partner-to-PIGP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGP→partner) and Y-score (partner→PIGP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.160	-3.160	.019	.019	3	1
UCEC	NF-kB-p65_pS536 →	-0.721	-2.999	.003	.035	3	1
UCEC	Notch1 →	+0.160	+2.817	.038	.036	3	1
UCEC	PDCD4 →	-0.857	-3.160	<.001	.019	3	1
UCEC	Rb_pS807_S811 →	-0.754	-3.169	<.001	.019	3	1
UCEC	4E-BP1_pS65 →	-0.272	-3.156	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

PIGP survival (RNA) · tumor vs normal (RNA) · all PIGP data types