PIGO

Across TCGA pan-cancer cohorts, PIGO mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PIGO data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIGO mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PIGO expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where PIGO mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.874	0.397	<.001	21	view →
PDAC	OS	Quartile	III,IV	0.853	0.194	.017	16	view →
LUAD	DFS	Tertile	II,III,IV	0.187	0.762	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PIGO–HNSC (DFS)

Open the HNSC breakdown →