Across TCGA pan-cancer cohorts, PIGN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIGN data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PIGN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGN expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where PIGN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.434	1.000	.012	12	view →
PDAC	OS	Median	III,IV	0.462	0.879	.020	12	view →
HNSC	OS	Quartile	II,III,IV	0.901	0.591	.011	10	view →
LSCC	DFS	Median	II,III,IV	0.840	0.580	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PIGN tumor-vs-normal RNA expression · all PIGN data types