PIGM

Across TCGA pan-cancer cohorts, PIGM mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PIGM’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PIGM mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PIGM is over-expressed in tumor.

LSCC, LUAD, and CCRCC are the cancer types where PIGM tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIGM mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.368	<.001	6	view →
LUAD	Female	All	+0.382	<.001	5	view →
CCRCC	All	All	+0.395	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PIGM–LSCC

Open the LSCC breakdown →