PIGH

Across TCGA patient cohorts, PIGH protein abundance is significantly associated with the RNA expression of many other genes, with 9,341 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PIGH-associated genes across cancer lineages are TIGD6, NME5, and ICAM2. Each is linked with PIGH in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGH-to-partner and partner-to-PIGH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIGH versus TIGD6 in CCRCC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGH→partner) and Y-score (partner→PIGH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TIGD6 →	+0.442	+0.574	.006	<.001	3	3
CCRCC	NME5 →	+1.379	+0.490	.003	.001	3	3
BRCA	ICAM2 →	-0.778	-0.530	<.001	<.001	3	2
OV	CHPT1 →	-0.577	-0.703	.006	.009	3	2
BRCA	GZMK →	-1.122	-0.388	<.001	.004	3	2
OV	SLC2A11 →	+0.873	+0.801	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,341 associations by consensus.

PIGH vs TIGD6 — CCRCC

Explore this scatter interactively →