PIGC

Across TCGA patient cohorts, PIGC RNA expression is significantly associated with the protein abundance of many other proteins, with 15,805 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIGC-associated proteins across cancer lineages are CDC73, TIPRL, and RPRD2. Each is linked with PIGC in more than 6 cancer types. Because this analysis shows association rather than direction, both PIGC-to-partner and partner-to-PIGC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIGC versus CDC73 in LSCC, with a Pearson correlation of 0.61.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGC→partner) and Y-score (partner→PIGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDC73 →	+0.242	+0.449	<.001	<.001	3	7
UCEC	TIPRL →	+0.307	+0.635	<.001	<.001	3	7
LUAD	RPRD2 →	+0.287	+0.492	<.001	<.001	3	7
LSCC	GATAD2B →	+0.392	+0.539	<.001	<.001	3	7
BRCA	PRCC →	+0.274	+0.368	<.001	<.001	3	6
OV	PRUNE1 →	+0.433	+0.527	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,805 associations by consensus.

PIGC vs CDC73 — LSCC

Explore this scatter interactively →