PIGC

Across TCGA patient cohorts, PIGC protein abundance is significantly associated with the RNA expression of many other genes, with 8,655 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PIGC-associated genes across cancer lineages are YARS1, TRIB3, and TGM5. Each is linked with PIGC in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGC-to-partner and partner-to-PIGC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIGC versus YARS1 in UCEC, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGC→partner) and Y-score (partner→PIGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YARS1 →	+0.596	+0.759	<.001	.008	3	2
UCEC	TRIB3 →	+2.165	+1.122	.001	.001	3	1
UCEC	TGM5 →	+2.839	+1.115	.001	.007	3	1
UCEC	GARS1 →	+0.715	+0.926	.002	<.001	3	1
UCEC	WNT3 →	+0.533	+0.783	.003	.006	3	1
UCEC	ULBP1 →	+0.863	+0.752	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,655 associations by consensus.

PIGC vs YARS1 — UCEC

Explore this scatter interactively →