PIGC

Across TCGA patient cohorts, PIGC mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGC-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Caspase-7-cleavedD198. Each is linked with PIGC in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGC-to-partner and partner-to-PIGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by PIGC-low versus PIGC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGC→partner) and Y-score (partner→PIGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.196	-2.459	.012	.019	3	1
UCEC	MEK1 →	+0.453	+3.321	.007	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.776	+2.189	.004	.034	3	1
UCEC	eIF4E →	+0.229	+3.000	.019	.036	2	1
UCEC	Shc_pY317 →	-0.185	-3.321	.009	.010	2	1
UCEC	ERK2 →	+0.284	+3.700	.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK_pT183_Y185 by PIGC expression — UCEC

Explore this box plot interactively →